Revitalização do sistema de cooperação do consumidor na Rússia; desenvolvimento sustentável do território e crescimento da qualidade de vida

The system of consumer cooperation has a certain potential in solving national problems related to the provision of employment and the quality of life of the population, as well as to the social reorganization of the village. The study shows that the cooperative system is characterized by the complementarity of traits (social and economic), the dialectical interaction of which serves as the basis for the formation of civil society (self-organization and voluntary cooperation of shareholders in the process of production and economic activity) and a peculiar locomotive of the evolution of society towards building socially-oriented market economy (non-commercial nature of activities and humanistic values). However, the emerging trend of losing the competitive positions of the consumer cooperative system in the regional consumer markets in Russia leads to an awareness of the need for institutional changes that would make it possible to fully utilize the economic and social potential of the development of consumer cooperation in the context of the structural transformation of Russian society. The authors offer practical recommendations on the design and formation of effective forms of management of economic entities in the cooperative sector. Complex nature of the economic resource requires its inclusion in the correlation algorithm of proactive management. Simulation of sustainable innovation development of the regional system of consumer cooperation is possible only using optimization-qualimetric modeling on the platform of the software product. Computer technologies create objective opportunities for creating the required model. The integrated computer space is able to rework the network of mathematical matrices, building a complete life cycle of an economic resource, consisting not only of collecting and analyzing information, but also the possibility of making operational management decisions.El sistema de cooperación del consumidor tiene cierto potencial para resolver los problemas nacionales relacionados con la provisión de empleo y la calidad de vida de la población, así como con la reorganización social de la aldea. El estudio muestra que el sistema cooperativo se caracteriza por la complementariedad de rasgos (sociales y económicos), cuya interacción dialéctica sirve de base para la formación de la sociedad civil (autoorganización y cooperación voluntaria de los accionistas en el proceso de producción económica) y una locomotora peculiar de la evolución de la sociedad hacia la construcción de una economía de mercado orientada socialmente (naturaleza no comercial de las actividades y valores humanísticos). Sin embargo, la tendencia emergente de perder las posiciones competitivas del sistema de cooperativas de consumo en los mercados de consumo regionales en Rusia lleva a una conciencia de la necesidad de cambios institucionales que permitan aprovechar plenamente el potencial económico y social del desarrollo del consumidor. Los autores ofrecen recomendaciones prácticas sobre el diseño y la formación de formas efectivas de gestión de entidades económicas en el sector cooperativo.  La naturaleza compleja del recurso económico requiere su inclusión en el algoritmo de correlación de la gestión proactiva. La simulación del desarrollo de innovación sostenible del sistema regional de cooperación del consumidor solo es posible mediante el uso del modelado optimizado y cualimétrico en la plataforma del producto de software. Las tecnologías informáticas crean oportunidades objetivas para crear el modelo requerido. El espacio informático integrado es capaz de volver a trabajar la red de matrices matemáticas, creando un ciclo de vida completo de un recurso económico, que consiste no solo en recopilar y analizar información, sino también en la posibilidad de tomar decisiones de gestión operativa.O sistema de cooperação do consumidor tem algum potencial para resolver problemas nacionais relacionados com a oferta de emprego e a qualidade de vida da população, bem como a reorganização social da aldeia. O estudo mostra que o sistema cooperativo é caracterizado pela complementaridade de características (sociais e econômicas), cuja interação dialética serve de base para a formação da sociedade civil (auto-organização e cooperação voluntária dos acionistas no processo de produção econômica) e uma locomotiva peculiar à evolução da sociedade para a construção de uma economia de mercado socialmente orientada (natureza não comercial de atividades e valores humanísticos). No entanto, a tendência emergente de perder as posições competitivas do sistema cooperativo de consumo nos mercados consumidores regionais da Rússia leva à conscientização da necessidade de mudanças institucionais que permitam a plena exploração do potencial econômico e social do desenvolvimento do consumidor. Os autores oferecem recomendações práticas sobre a concepção e formação de formas eficazes de gestão de entidades econômicas no setor cooperativo. A natureza complexa do recurso econômico requer sua inclusão no algoritmo de correlação do gerenciamento proativo. A simulação do desenvolvimento da inovação sustentável do sistema regional de cooperação do consumidor só é possível através do uso de modelagem otimizada e qualitativa na plataforma de produtos de software. As tecnologias computacionais criam oportunidades objetivas para criar o modelo necessário. O espaço computacional integrado é capaz de retrabalhar a rede de matrizes matemáticas, criando um ciclo de vida completo de um recurso econômico, que consiste não apenas em coletar e analisar informações, mas também na possibilidade de tomar decisões de gerenciamento operacional

High concentrations of several metabolites and growth factors in patients with delayed lower limb fracture healing

Purpose To study concentrations of metabolites and growth factors as well as hematological parameters in patients with delayed lower limb fracture healing Material and methods Concentrations of several metabolites and growth factors as well as hematological parameters were studied in 13 patients with a delay in healing of femoral and tibial fractures after 7 to 11 months following injury. Seven patients with consolidated diaphyseal femoral and tibial fractures examined 10 to 12 months after the injury were a control group. Ten healthy subjects that did not have any history of fractures were a reference group. Results Unlike individuals of control and reference groups, patients with delayed fracture healing showed significantly higher concentrations of lactate, triglycerides, TGF-α and TGF-β2 in their serum while IGF-1 levels were significantly lower. Hematology tests did not show differences between the groups. Conclusion Local hypoxia, acidosis and expression of GFs that support osteolysis were the main pathophysiological processes that could cause the delay in long-bone fracture healing

Nucleosome Chiral Transition under Positive Torsional Stress in Single Chromatin Fibers

Using magnetic tweezers to investigate the mechanical response of single chromatin fibers, we show that fibers submitted to large positive torsion transiently trap positive turns, at a rate of one turn per nucleosome. A comparison with the response of fibers of tetrasomes (the (H3-H4)2 tetramer bound with ~50 bp of DNA) obtained by depletion of H2A-H2B dimers, suggests that the trapping reflects a nucleosome chiral transition to a metastable form built on the previously documented righthanded tetrasome. In view of its low energy, <8 kT, we propose this transition is physiologically relevant and serves to break the docking of the dimers on the tetramer which in the absence of other factors exerts a strong block against elongation of transcription by the main RNA polymerase.Comment: 33 pages (double spacing), 7 figure

Hydrology needed to manage droughts: the 2015 European case

Hydrology needed to manage droughts: the 2015 European cas

The challenge of unprecedented floods and droughts in risk management

Risk management has reduced vulnerability to floods and droughts globally1,2, yet their impacts are still increasing3. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data4,5. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impacts of floods and droughts but faces difficulties in reducing the impacts of unprecedented events of a magnitude not previously experienced. If the second event was much more hazardous than the first, its impact was almost always higher. This is because management was not designed to deal with such extreme events: for example, they exceeded the design levels of levees and reservoirs. In two success stories, the impact of the second, more hazardous, event was lower, as a result of improved risk management governance and high investment in integrated management. The observed difficulty of managing unprecedented events is alarming, given that more extreme hydrological events are projected owing to climate change3

Changing climate both increases and decreases European river floods

Climate change has led to concerns about increasing river floods resulting from the greater water-holding capacity of a warmer atmosphere. These concerns are reinforced by evidence of increasing economic losses associated with flooding in many parts of the world, including Europe. Any changes in river floods would have lasting implications for the design of flood protection measures and flood risk zoning. However, existing studies have been unable to identify a consistent continental-scale climatic-change signal in flood discharge observations in Europe, because of the limited spatial coverage and number of hydrometric stations. Here we demonstrate clear regional patterns of both increases and decreases in observed river flood discharges in the past five decades in Europe, which are manifestations of a changing climate. Our results—arising from the most complete database of European flooding so far—suggest that: increasing autumn and winter rainfall has resulted in increasing floods in northwestern Europe; decreasing precipitation and increasing evaporation have led to decreasing floods in medium and large catchments in southern Europe; and decreasing snow cover and snowmelt, resulting from warmer temperatures, have led to decreasing floods in eastern Europe. Regional flood discharge trends in Europe range from an increase of about 11 per cent per decade to a decrease of 23 per cent. Notwithstanding the spatial and temporal heterogeneity of the observational record, the flood changes identified here are broadly consistent with climate model projections for the next century, suggesting that climate-driven changes are already happening and supporting calls for the consideration of climate change in flood risk management

Panta Rhei benchmark dataset: socio-hydrological data of paired events of floods and droughts

As the adverse impacts of hydrological extremes increase in many regions of the world, a better understanding of the drivers of changes in risk and impacts is essential for effective flood and drought risk management and climate adaptation. However, there is currently a lack of comprehensive, empirical data about the processes, interactions and feedbacks in complex human-water systems leading to flood and drought impacts. Here we present a benchmark dataset containing socio-hydrological data of paired events, i.e., two floods or two droughts that occurred in the same area. The 45 paired events occurred in 42 different study areas and cover a wide range of socio-economic and hydro-climatic conditions. The dataset is unique in covering both floods and droughts, in the number of cases assessed, and in the quantity of socio-hydrological data. The benchmark dataset comprises: 1) detailed review style reports about the events and key processes between the two events of a pair; 2) the key data table containing variables that assess the indicators which characterise management shortcomings, hazard, exposure, vulnerability and impacts of all events; 3) a table of the indicators-of-change that indicate the differences between the first and second event of a pair. The advantages of the dataset are that it enables comparative analyses across all the paired events based on the indicators-of-change and allows for detailed context- and location-specific assessments based on the extensive data and reports of the individual study areas. The dataset can be used by the scientific community for exploratory data analyses e.g. focused on causal links between risk management, changes in hazard, exposure and vulnerability and flood or drought impacts. The data can also be used for the development, calibration and validation of socio-hydrological models. The dataset is available to the public through the GFZ Data Services (Kreibich et al. 2023, link for review: https://dataservices.gfz-potsdam.de/panmetaworks/review/923c14519deb04f83815ce108b48dd2581d57b90ce069bec9c948361028b8c85/).</p

Changing climate shifts timing of European floods

A warming climate is expected to have an impact on the magnitude and timing of river floods; however, no consistent large-scale climate change signal in observed flood magnitudes has been identified so far. We analyzed the timing of river floods in Europe over the past five decades, using a pan-European database from 4262 observational hydrometric stations, and found clear patterns of change in flood timing. Warmer temperatures have led to earlier spring snowmelt floods throughout northeastern Europe; delayed winter storms associated with polar warming have led to later winter floods around the North Sea and some sectors of the Mediterranean coast; and earlier soil moisture maxima have led to earlier winter floods in western Europe. Our results highlight the existence of a clear climate signal in flood observations at the continental scale

Megafloods in Europe can be anticipated from observations in hydrologically similar catchments

Megafloods that far exceed previously observed records often take citizens and experts by surprise, resulting in extremely severe damage and loss of life. Existing methods based on local and regional information rarely go beyond national borders and cannot predict these floods well because of limited data on megafloods, and because flood generation processes of extremes differ from those of smaller, more frequently observed events. Here we analyse river discharge observations from over 8,000 gauging stations across Europe and show that recent megafloods could have been anticipated from those previously observed in other places in Europe. Almost all observed megafloods (95.5%) fall within the envelope values estimated from previous floods in other similar places on the continent, implying that local surprises are not surprising at the continental scale. This holds also for older events, indicating that megafloods have not changed much in time relative to their spatial variability. The underlying concept of the study is that catchments with similar flood generation processes produce similar outliers. It is thus essential to transcend national boundaries and learn from other places across the continent to avoid surprises and save lives